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Although 6-phosphoglucono--lactone is hydrolytically unstable and can undergo spontaneous (nonenzymatic) ring-opening at a significant rate, this hydrolysis reaction is greatly accelerated in the cell by the enzyme 6-phosphogluconolactonase (EC 3.1.1.31)

Magn Reson Imaging 28:163170 Zhang R, Wu W, Luo S (2011) Different behaviors of glutathione in aqueous and DMSO solutions: molecular dynamics simulation and NMR experimental study

To test if this increased lipolytic activity was functionally crucial for efferocytosis, we treated M2 macrophages with Orlistat, a pan-lipase inhibitor, and observed a dose-dependent suppression of efferocytosis (Fig

Bartolini L, Muscal E

Salama A, Elsayeh B, Ismaiel I, El-Shenawy S