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Primarily, CHAC1 is transcriptionally regulated by ATF4, a key player in the integrated stress response (ISR), which is activated during conditions like amino acid deprivation and oxidative stress (Xu Y

doi: 10.1039/D0SM00966K

Smoking and drinking habits as risk factors for hearing loss in the elderly: Epidemiological study of subjects undergoing routine health checks in Aichi, Japan

Together, these diverse yet interconnected mechanisms indicate that AD is unlikely to be effectively treated through single-target approaches and instead requires delivery strategies capable of addressing multiple pathological pathways

10.1038/sj.jid.5700257 10.1038/sj.jid.5700257 [DOI] [PubMed] [Google Scholar] Schoenfeld JD, Sibenaller ZA, Mapuskar KA et al (2017) O2- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate