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This is a secondary mechanism, but clinically relevant

Because acute and chronic exposure to TiO 2 particles also induce inflammatory responses in the airways and alveolar spaces of rats 68,79,80,81 , TiO 2 -treated rats are a useful model for studying epithelial responses to PM 10 particles

Enzyme replacement therapy in Fabry disease: a randomized controlled trial

It shouldn't assume users always make perfect or even wise choices