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Iron overload can lead to abnormalities that affect the functions of cells or tissues

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Complementing this, Wu et al., 2019 studied AgNPs of various diameters (3.2, 20.7, 54.7, and 93.6 nm) in B16 mouse melanoma cells and found that nanoparticle size not only affected uptake efficiency but also dictated the endocytic pathways involved

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This is why many people who take standard supplements do not see a significant change in their cellular levels