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Description
In the ALS spinal cord, 12 serine phosphorylation sites (S373, S375, S379, S387, S389, S393, S395, S403, S404, S407, S409, and S410) were identified on TDP-43 CTD by mass spectrometry 91
Its mechanisms involve modulating oxidative stress, inflammatory signaling, apoptosis, and immune regulation
Using this approach, we identified monocytes with cytosolic ASC speck formation associated with active caspase-1/4/5, represented by FLICA + ASC-speck + cells ( Figure 2C , Merge panel)
externally peer reviewed
Elkanah et al., 2022)
