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Rigorous PK/PD coupling, standardized formulations, context-specific trial design (prevention vs therapy), and genotype or biomarker-stratified is therefore needed in rational translation so as to maximize benefit and minimize harm

Subsequently, infiltrating inflammatory mediators and immune cells can trigger reactive activation of microglia and astrocytes, promoting further inflammatory signaling within the CNS and thereby sustaining a neuroinflammatory microenvironment (Linnerbauer et al., 2020

Membranes were washed 3x for 10 min with TBST and subsequently incubated for 1 h at room temperature with appropriate horseradish peroxidase-conjugated secondary antibodies (Sigma-Aldrich, NA934-1ML or NA931-1ML) diluted (1:10,000) in 5% (w/v) milk TBST
