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Description
G protein-coupled receptor kinases
Senescent cells promote inflammation and fibrosis by activating the p16/p21-Rb pathway and secreting senescence-associated secretory phenotype (SASP) factors, including IL-1, IL-6, IL-8, TGF-, plasminogen activator inhibitor (PAI), and insulin-like growth factor-1(IGF-1) (Lin et al., 2022
GI losses, the use of diuretics, hemorrhages, and endocrine impairments such as adrenal insufficiency, ACTH (adrenocorticotropic hormone) deficit, or severe hypothyroidism are common causes of low sodium levels
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