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Vadal G, Russo F, Ambrosio L, Loppini M, Denaro V

These in vitro findings reinforce that natural molecules can directly safeguard neuronal cells, something not observed with levodopa in cell culture (levodopa in vitro can actually be toxic to neurons at high concentrations due to oxidative byproducts) [60, 61]
Psychedelics have shown promising results in clinical trials, emerging as potential treatments for psychiatric conditions with high prevalence and morbidity, such as major depression and anxiety (Davis et al., 2021

It is likely that mitochondrial biogenesis is an indirect response to improvement in B12 availability, recognizing that the two enzymes to which B12 is a co-factor are both linked to mitochondrial metabolism
