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*Correspondence: Yi Hua, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In mammals, the mtDNA encodes only 37 genes, of which 13 are subunits of the OXPHOS (complexes I, III, IV, and V), two are rRNA genes, and 22 are tRNA genes required for mitochondrial protein synthesis