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A negative regulatory protein, Keap1, has been shown under non-stressed conditions to keep Nrf2 in a silent state [23]
doi: 10.1016/s0167-4781(00)00238-4
CD4+CD25(high)CD127(low/-) Treg cell frequency from peripheral blood correlates with disease activity in patients with rheumatoid arthritis
Notably, many NAs are classified as probable or possible human carcinogens by the International Agency for Research on Cancer (IARC) (Preston-Martin 1987)

The CellChatDB.mouse database, which contains secreted signaling, ECM-receptor, and cell-cell contact ligandreceptor (LR) interactions, was used
