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The researchers speculated that the increased lean body mass was due to more efficient muscle protein synthesis from the less-degraded l-citrulline in the bloodstream
(2020) N-Acetylcysteine as an adjunctive treatment for bipolar depression and major depressive disorder: a systematic review and meta-analysis of double-blind, randomized placebo-controlled trials

Mattson ML, Gleichman M, Cheng A

Ultimately, this review proposes that PEM may arise from a complex interplay among mitochondrial dysfunction, immune activation, and neuroinflammation, which together form a self-perpetuating loop of energy exhaustion - inflammation amplification, potentially contributing to the chronic and multi-system nature of PEM symptoms

Hippocampal pdha1 gene knockout inhibits the warburg effect leading to cognitive dysfunction and attenuates the beneficial effects of zibupiyin recipe on cognition
