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[DOI] [PubMed] [Google Scholar] 39.Vijayalakshmi M., Ruckmani K

This is achieved in an oxidation step mediated by PDI oxidoreductases (protein disulfide isomerases) [for details, see Lenzen (2017)].The ER acts as a H 2 O 2 store, keeping a greater amount of the generated H 2 O 2 in the ER due to a limited efflux of H 2 O 2 into the cytosolic space

To defend against oxidative damage, organisms have developed defenses dependent on antioxidant enzymes and damage repair

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2i and Supplementary Table 11)
