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A meta-analysis of 23 randomized controlled trials found that carnitine significantly improved sperm motility (7%), sperm concentration, and morphology (5%) compared to other antioxidants [97]

Cheng JZ, Singhal SS, Sharma A, Saini M, Yang Y, Awasthi S, Zimniak P, Awasthi YC

Low plasma content of tryptophan has been reported in patients with depression ( Compared with CUMS group, the content of brain metabolites in the ZZCD group was reversed to the normal level, and the disturbed metabolic pathways were restored, which suggesting the antidepressant effect of ZZCD on CUMS rats and revealing the underlying mechanism associated with the improvement of brain metabolism in Phenylalanine, tyrosine and tryptophan biosynthesis, Glutathione metabolism, Phenylalanine metabolism, Lysine degradation, Cysteine and methionine metabolism, Tyrosine metabolism, and Tryptophan metabolism

The gradually increasing number of RNA-based medications on the market, coupled with the growing body of preclinical and clinical studies, underscores the rising significance of these gene therapy modalities