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The big weight loss seen in these trials, along with its potential effects on energy expenditure and fat oxidation, makes tesofensine a strong candidate to tackle obesity around the world

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Similar to GLP-1 and other analogues, the mechanism involves raising the levels of cAMP, along with the activation of other downstream signalling pathways [88]

Setting: The treatment must be done in a proper hospital or clinic setting under the supervision of a healthcare professional

Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence