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The common symptoms of pernicious anemia include: Fatigue, lack of energy, or lightheadedness when standing up or with exertion Pale skin Diarrhea or constipation Nausea, vomiting Loss of appetite Tingling feelings or pain Trouble walking Uncontrollable muscle movements Confusion and memory loss Headaches To diagnose Pernicious Anemia, in addition to a CBC, serum folate, iron, and iron-binding capacity tests can help diagnose pernicious anemia or another type of anemia

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However, more RCTs of vitamin B 12 supplementation and analysis of various markers (eg, total B 12 , holotranscobalamin, total Hcy and MMA, total folic acid, and if possible, polymorphism and/or methylation of genes) are needed to precisely identify the status of this micronutrient (before and after) in people with or without COVID-19 and thus facilitate the proper choice of vitamin B 12 form to be administered in treatment