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[6] [7] The SYNERGY-NASH phase 2 trial has investigated histological outcomes in patients with steatohepatitis and fibrosis, with preliminary data suggesting that a proportion of participants achieved resolution of hepatic steatosis, defined as liver fat content below 5%

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The small molecule compound D34-919, which targets the ALDH1A3-PKM2 interaction, has demonstrated clinically significant outcomes

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