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Description
S5B and S6A)
recently identified through a genome wide association study a novel lead single nucleotide polymorphism (SNP) that fell in an intronic region within the GLi3 gene
These pro-inflammatory cytokines contribute to tumor development in both experimental models but their distinct expression profile in control versus Stard7-inactivated epithelial cells reflects the opposite outcome on tumor development in both models due to distinct Apc status
This explains the lack of tolerance and dependence liability observed in animal studies
Turkova, A
