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The sandwich method is a simple way to reduce irritation: Apply a thin layer of moisturizer on clean, dry skin Apply a pea-sized amount of tretinoin (avoid corners of nose, mouth, and eyelids) Finish with another thin layer of moisturizer Two important details: Start slow: 23 nights/week, then increase only if your skin is calm

Free Radical Biol Med 182:206218

Dont vigorously shake the vial it damages the peptide

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