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Description

The therapeutic cascade includes a significant upregulation of VEGF and TGF-, markers of angiogenesis and tissue remodelling, alongside an increase in IL-6, indicating an acute phase response

(3) Reperfusion or immune bursts occur over milliseconds to seconds and are often missed ex vivo, necessitating time-stamped assays and, when feasible, low-phototoxicity in situ imaging/recording

van Ophoven, A., Pokupic, S., Heinecke, A

however, the foundational mechanisms and potential for therapeutic intervention remain inadequately understood and warrant further research (Uchida and Bolli, 2018