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By degrading toxic aldehydes, ALDH2 decreases intracellular aldehyde levels, mitigating their harmful effects on cellular integrity (39)
doi: 10.1080/10641963.2019.1676770
Overall, this process is negatively regulated by Wnt/-catenin signaling
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The glutathionylated/oxidized enzymes were again purified via Ni-NTA affinitiy chromatograpghy followed by desalting on a PD-10 column as described above
