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Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms

However, it is believed that the anticancer activity of cisplatin is because of its interaction with DNA which inhibits the replication process leading to a disrupted biological process

Caution is again the rule, especially at younger ages, due to reports of serious adverse events (such as tachycardia, insomnia, agitation, dizziness and anxiety) in elevated modafinil doses (Spiller et al., 2009), and in fact, the manufacturer recommends against use of modafinil in younger children

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Lin CS, Jwo JS, Lee CH