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doi: 10.2337/diabetes.51.1.174

Furthermore, tobacco smoke is one factor that significantly contributes to oxidative stress and, consequently, to changes in the epigenetic machinery involving methylation (Mecocci and Polidori, 2012)

OxS is usually defined as Sa physiologically significant alteration in redox status resulting from an overproduction of reactive oxygen species (ROS) and/or a deficiency in antioxidant protective mechanisms [6]

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