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The inhibitory effects of chronic exposure of vitamin B12 on glutamate-induced neurotoxicity were determined in cell culture, probably by altering the membrane properties through S-adenosylmethionine (SAM)-mediated methylation [26, 27]

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B12 Intramuscular Dose Recommendations The usual dose for vitamin B12 injections is 1000 mcg (1 mg)

Standard initial therapy for patients without neurological involvement is 1000 mcg intramuscularly (i.m.) three times a week for 2 weeks
