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Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J (2017) Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study

Moreover, old stored blood has high levels of leucocyte-secreted cytokines that significantly raise the risk of non-hemolytic febrile transfusion reactions

Toxicol Sci 68, 22636

While preliminary studies are promising, further human research is needed to confirm these mechanisms
