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Patients in the study were required to be between 18 and 75 years of age with histologically-confirmed Dukes' stage C colon cancer with at least one positive lymph node and to have undergone (within 8 weeks prior to randomization) complete resection of the primary tumor without macroscopic or microscopic evidence of remaining tumor

Nevertheless, it has also been found that H 2 S may have anti-tumor properties by inducing apoptosis and inhibiting cell proliferation

Hyperglycemia triggers ROS production through multiple pathways, including the polyol pathway, protein kinase C (PKC) activation, and advanced glycation end product (AGE) formation

Insulin-like growth factor (IGF)-II: a potent stimulant for proliferation