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If side effects occur, they are usually mild and temporary

[DOI] [PubMed] [Google Scholar] Barbosa C.D., Uetanabaro A.P.T., Santos W.C.R., Caetano R.G., Albano H., Kato R., Cosenza G.P., Azeredo A., Ges-Neto A., Rosa C.A

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This classification system of mechanismsranging from direct cell killing to multidimensional physiological regulationestablishes a theoretical foundation for the precise application of diverse natural products

Recent evidence has shown that at moderate concentrations, nitric oxide (NO), superoxide anion and related reactive species play an important role as regulatory mediators in cell-signalling processes and that many of the ROS-mediated responses actually protect the cells against oxidative stress and re-establish redox balance [4]