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Metabolic effects, including weight change, insulin resistance, and altered appetite, further affect sex hormones and ovulatory regularity

In addition to variations in the total amount of melanin [8, 9], the size, distribution, and fate of melanosomes within keratinocytes are key determinants in the diversity in skin pigmentation [11, 17, 18]

Thus, knowing the identity, functions, and regulation of spRNAs may have direct relevance to the diagnosis of male infertility and developing RNA-based therapies or contraceptives

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