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Previous studies showed that the expression of xCT gene and protein is decreased by chronic nicotine exposure (Quintanilla et al., 2021)

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The work was supported, in part, by grants from the following: The National Natural Science Foundation-Excellent Young Scientists Fund 2020 (Ref: 32022087) and Young Scientist Fund 2023 (32300643) (K.H.-M.C.)

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Conclusions In this review, we covered the roles of glutamine in the intestine, including the regulation of enterocyte proliferation, maintenance of tight-junction proteins, modulation of inflammatory pathways, such as NF-B and STAT signaling, and protection against apoptosis and cellular stresses, which are summarized in Figure 1