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It has a long half-life making once-daily dosing possible

NGRA aims to conduct safety assessments that are human-relevant, exposure-led, hypothesis-driven and designed to prevent harm ( in vitro bioactivity at human-relevant concentrations and, consequently, adverse health effects, in lieu of replicating apical endpoints that would traditionally be obtained using high-dose animal studies (OECD, 2017

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Additionally, neural repression of the KCC2 could affect synaptic maturation, compromising the function of inhibitory cortical neurons (Yeo et al., 2013)

Superoxide dismutase mimetic GC4419 enhances the oxidation of pharmacological ascorbate and its anticancer effects in an H 2 O 2 -dependent manner