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Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial

We also showed that HNE can detrimentally affect proteins and cellular pathways other than those related to glucose metabolism as well as lead to loss of bilayer lipid asymmetry, with both factors leading to neuronal death as well (135137, 140, 141)

10.14336/AD.2021.0824 37 Djoumbou-FeunangY.FiamonciniJ.Gil-de-la-FuenteA.GreinerR.ManachC.WishartD

doi: 10.1016/j.micres.2025.128203

Another study shows that this compound demonstrated a cytoprotective effect against H2O2-induced apoptotic cell death in human intestinal epithelial cells (HCT116)
