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At the translational level, rigorous evaluation of the long-term efficacy and safety of selective receptor modulators (SERMs, SPRMs), aromatase inhibitors, and their combination with antioxidant therapies is essential

NRF2 provides a protective effect in melanocytes in response to both UV irradiation and oxidative stress 30,31 , through transcriptional upregulation of the antioxidant response element (ARE) genes including Superoxide dismutase-1 (SOD-1), Glutathione peroxidase-1 (GP-1), Glutathione reductase-1 (GR-1), Catalase and Heme oxygenase-1 (HO-1) 38,39,40

The regulatory role of miRNA sets them apart as particularly promising biomarkers in liquid biopsy

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