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In addition, orofacial nerve injury (IONI) induced neuropathic pain can up-regulate the IGF-1, while subcutaneous injection of IGF-1 neutralizing antibody can recover the mechanical head withdrawal reflex thresholds (MHWTs) significantly[76]
Previous studies have demonstrated that binding of adrenergic drugs to intact OPR at these concentrations results in increased opioid binding [67,68]
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[Abstract]2021 Jun 10:12:690821
