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[76] In 2012, Santos collaborated with Javier Reyes in Mga Mumunting Lihim with Iza Calzado, Janice de Belen, and Agot Isidro

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Researchers suggested that these effects were due to enhanced blood flow and oxygen supply to the muscle tissue via improved endothelial function thereby reducing hypoxia-induced cellular and biochemical disruptions. This means that L-carnitine improves the function of blood vessel liningsthe endotheliumleading to increased blood flow, better oxygen delivery to muscles and tissues, and also less disruption of normal cell function that occurs with hypoxia, or lowered oxygen supply