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USPs 20 and 33, but not their inactive forms, increase the cAMP signals obtained upon repeated stimulation of cells after an initial agonist treatment, suggesting that USPs 20 and 33 also promote efficient resensitization of 2 ARs [87]

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[DOI] [PMC free article] [PubMed] [Google Scholar] GPR55 protein expression summary - The Human Protein Atlas n.d Accessed 19 Jul 2023 Ghovanloo MR, Ruben PC

Furthermore, these haplotype associations require further analysis to exclude nearby HLA gene variantswhich may influence the observed immune phenotype due to linkage disequilibrium with specific C4 alleles (123)