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Any new, changing, asymmetrical or irregular pigmented lip lesion warrants assessment with dermoscopy and often biopsy before any cosmetic treatment Treatment confirmed labial melanotic macules can be left alone or treated cosmetically with laser ablation or excision biopsy if cosmetically prominent Other benign lesions Fibroma firm fibrous nodule on the inner lip, usually from chronic minor friction trauma

The results should be reported in international units to standardize data29, although the dynamic ranges differ and the results can be difficult to compare between assays, as noted in Table 4

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