what is melanotic macules macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Oral Mucosal Melanosis | IntechOpen

Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)

Depression: a new animal model sensitive to antidepressant treatments

In MM patients, 24% of tumors exhibit copy number loss of CDKN2A ( CDK4 , CCND1 , and MDM2 are amplified in 28%, 18%, and 19% of samples respectively, and TP53 mutations occur in 9.0% of MMs ( CDKN2A loss than MM, MM tends to show a greater frequency of CCND1 and CDK4 amplification (120, 122), implying CDK4 blocking agents may achieve a desired anti-tumor effect on MM

Significant differences were observed in the proportion of stage III melanosomes ( p = 2.575e-7, effect size r = 0.8358) and stage II melanosomes ( p = 1.568e-8, effect size r = -0.9054)

Protects Against Oxidative Stress Your brain constantly battles harmful molecules called free radicals