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Secondary mechanisms include modulation of inflammatory cytokines and interaction with growth factor receptors, contributing to its broad regenerative profile in research models focused on musculoskeletal, gastrointestinal, and neural tissues

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from an independent Chinese research group (PMID: 34827486) demonstrated that Dihexa rescued cognitive impairment in APP/PS1 Alzheimer's disease model mice via the PI3K/AKT signaling pathway, providing the first independent replication of cognitive enhancement effects

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Investigators tapered or paused doses if intolerance developed (57.4% maintained maximum dose at week 68

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