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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

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Lancet Respiriratory Med

With the help of other antioxidative compounds, -tocopherol decreases the level of devastating ROS, chiefly 1 O 2 and HO in the cell

Overall there are four different pathways: (a) the transcellular route used by small hydrophilic and lipophilic compounds
