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More and more evidence shows that the ubiquitination of RTK is the key to its lysosomal degradation and recruitment of the ubiquitin protein ligase Cbl family is required for ligand-induced degradation of many RTKs

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[DOI] [PubMed] [Google Scholar] 97.Blanusa M., Varnai V.M., Piasek M., Kostial K

Single ggt or pepT deletion and a double deletion were conducted, obtaining the mutants MG003, MG004 and MG034, respectively

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