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This effect with the disruption of the brain gut axis may contribute to the development of functional dyspepsia

Clinical evidence pertaining to migraines, oxidative stress, and neurogenic inflammation, along with experimental evidence of topiramates antioxidative and anti-inflammatory effects, provide strong hypothetical support for the idea that topiramate may treat migraines by blocking oxidative stress and neurogenic inflammation pathways

Jul 12 2021;13(7)doi:10.3390/nu13072381

Its presence supports phase II detoxification enzyme systems including glutathione S-transferases and quinone reductase, facilitating elimination of xenobiotics and carcinogens