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Footnotes Edited by: Andrea Martinuzzi, Eugenio Medea (IRCCS), Italy Reviewed by: Pooja A

however, the relative contribution of each is still unknown and calls for carefully planned clinical trials that consider weight fluctuations

Shuaibin Zhang, Bing Zhou, Yanyuan Kang, Xia Cui, Ao Liu, Angelique Deleris, Maxim VC Greenberg, Xiekui Cui, Qi Qiu, Falong Lu, James A Wohlschlegel, Steven E Jacobsen and Xiaofeng Cao, "C-terminal domains of histone demethylase JMJ14 interact with a pair of NAC transcription factors to mediate specific chromatin association", Cell Discovery 1 (15003): 1-13 (2015)

For example, a decision to lower the lipophilicity in an attempt to increase half-life may result in decreasing half-life