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A notable example is the previously mentioned Maric et al., 2022 study and the accompanying University of Missouri press release from November 2022

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Those animals that learn to run in a wheel to escape tail shock subsequently learn to avoid shock in other apparati (typically a shuttle box), in contrast to animals that learn that their attempts to escape a shock are futile, and then go on to fail to avoid subsequent shuttle box shocks [178]

They are exceptionally vulnerable