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Leptin responsiveness restored by amylin agonism in diet-induced obesity evidence from nonclinical and clinical studies

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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

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Despite its prevalence, the methyl group is not regarded as an independent chemical substance because it is always present as part of another molecule