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Visentin, M., Zhao, R

10.1021/acsbiomaterials.2c00023 72 MaX.FengY.WangT.LeiW.LiX.ZhouD.et al (2017)

In chronic liver damage, HSCs transdifferentiate from a quiescent to an activated state and are responsible for collagen deposition in the liver tissue, playing a key role in the fibrosis process

This means that even if in basal conditions the GSH levels are similar, after challenges with drugs or pollutants requiring the GSH-dependent detoxification system, the decrease of GSH is more evident in males than in females

Similarly, in breast cancer, acacetin can promote the expression of RIPK1 and RIPK3 and the production of ROS, resulting in cell necroptosis (Kandhari et al., 2023)