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Klotho is a transmembrane protein that acts as a coreceptor for fibroblast growth factor 23 (FGF23), a hormone involved in phosphate and calcium homeostasis

However, how these proteins partner within a CRL is not clear

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The organoids exhibit key liver functions, including drug metabolism, serum protein production, urea synthesis and coagulation factor production, with preserved post-translational modifications such as N-glycosylation and functionality