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7.5 Critical discussion of translational challenges The translation of ferroptosis-targeting agents for AD faces multiple interconnected challenges, with BBB penetration, off-target effects, long-term safety, and perturbations of iron metabolism and immune function being the most prominent

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For example, transcription factor E3 (TFE3) has been found to regulate ROS-mediated autophagic dysfunction, alleviate ERS and promote neuronal survival