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Women are more commonly affected than men, and it tends to run in families

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ACE2 activator diminazene aceturate ameliorates Alzheimers disease-like neuropathology and rescues cognitive impairment in SAMP8 mice

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PINK1 insufficiency functions as an early regulator of neuronal innate immunity, since PINK1 /Parkin might lower inflammatory circumstances that initiate immune response-eliciting pathways by cutting mitochondrial antigen presentation in the mouse model of PD [379,380]