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The treatment arsenal for GBM includes surgery, radiation therapy, TMZ, tumor-treating fields, and a handful of other chemotherapies such as lomustine (CCNU) and carmustine (BCNU), but invariably these agents ultimately fail to provide long-term tumor control

Protein concentrations were adjusted using Quick Start Bradford 1 Dye Reagent (Bio-Rad, 5000205)

On the whole, the most consistent finding is that mGlu 2/3 activation could be useful for preventing relapse induced by environmental cues across a wide range of drugs of abuse

Second, fecal metabolism may reflect the final results of the interactions of diet, microbiota, and intestinal function