glutathione depletion-methylation block in cfs depletion induces ferroptosis, autophagy, and premature cell senescence retinal pigment epithelial cells JCI - Hepatic glutathione depletion

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Collectively, our results highlight the limitation of APR-246 as a p53-rescuing drug because of its overwhelming off-target effects on the redox system at doses that are sufficient to induce ferroptosis but insufficient to rescue mutant p53.

We concluded that the immobilized protein remained bound to the column after elution with low pH, allowing the reuse of the column for alternative uses, such as screening for other proteinprotein interactions using SPINK3 as the bait.

Importance of Glutathione