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There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.g., impaired kidney and/or liver function, or concomitant use of other drugs

Additionally, stress-inducing agents such as tunicamycin, thapsigargin and histidinol have been shown to modulate CHAC1 regulation, indicating its involvement not only during ER stress but also in the context of the ISR ( CHAC1 promoter is the primary mechanism for the transcriptional upregulation of the gene

Clinicopathological features and prognosis of papillary thyroid cancer patients with type 2 diabetes mellitus

Severe kidney impairment and food intake can influence the pharmacokinetic parameters of ALA [54, 55]